The University of Iowa Pharmaceuticals offers sterile pharmaceutical products development and manufacturing. Let us help you meet your needs.


Sterile Products

Lyophilization Cycle Development


Clinical Supply Manufacturing


Small Scale Commercial Manufacturing


Analytical Method Development and Validation


Routine Quality Control Analysis


Stability Assessment


Formulation Development


Comparator Products


Powder in a Bottle


Preformulation Studies


Active Pharmaceutical Ingredient (API) and Excipient Release Testing


QP Release Services


Sterile Liquid FillingSterile Pharmaceutical Products

The University of Iowa Pharmaceuticals (UIP) knows that sterile products are critical.

The Sterile Products Group has three ISO Class 6 Clean Rooms with Class 5 (Class 100) aseptic work areas, one of which is interfaced with a 48 square foot Hull Lyophilizer with clean in-place and steam in-place capability.

Sterile pharmaceutical products are prepared by sterile filling solutions into vials. After filling, vials can undergo lyophilization or terminal sterilization. Batch sizes can range from a few hundred to approximately 4,000 vials depending on the finished fill volume of the sterile products. Differential air pressures, along with other measures, including cleaning verification and dedicated product contact equipment components, are used to prevent cross-contamination.

Component preparation equipment includes:

  • Steriline vial washer
  • Cozzoli stopper washer
  • Getinge pass-through autoclave
  • Gruenberg dry heat oven.

Key Clean Room filling and finishing equipment includes:

  • Flexicon filling
  • Stoppering
  • Crimp sealing machine
  • Cozzoli vial filling
  • Stoppering machine
  • Westcapper crimp sealing machine

UIP is capable of developing lyophilization cycles.


Hull 48 Square Foot HY-PRO LyophilizerOnce produced, all products are 100 percent inspected for quality defects.  UIP has the ability to apply labeling to finished dosage units. If desired, patient kits can be assembled and materials can be shipped directly to clinical sites.


To learn more about our sterile pharmaceutical products manufacturing and packaging capabilities, please Contact Us or review our Full Equipment List here.