University of Iowa

Publication

UIP Director, Mickey L. Wells, PhD, was the primary author of a paper published in AAPS' PharmSciTech journal. The title of the paper is "Investigation into the Dissolution Rate Increase on Storage of Wellbutrin SR® 100 mg Tablets". The paper describes investigation of the cause of dissolution rate increases observed after storage of Wellbutrin SR® 100 mg Tablets (a hydrophillic matrix sustained release tablet) and the ultimate formulation modifications utilized to address the problem. UIP personnel have extensive experience formulating both hydrophilic matrix and coated sustained release solid oral dosage forms using a variety of polymers.