University of Iowa

UI Pharmaceuticals Provides a Full Range of Services to Support Comparator Studies

UI Pharmaceuticals has been preparing clinical supplies for blinded clinical trials using over-encapsulation and other approaches for almost 45 years. Let us help you successfully blind drug product for your clinical trial.

comparator product machine
The University of Iowa Pharmaceuticals’ (UIP) Non-Sterile Products Group has the capability to prepare comparator drugs for clinical trials via a variety of means, depending on the characteristics of the dosage forms.

Techniques that can be used include:

  • Placing products into empty capsule shells and overfilling with inert powders (over-encapsulation)
  • Milling commercially available products and filling the resultant powder into empty capsule shells
  • Removing ink logos from commercially available tablets or capsules
  • Film coating over existing brand marking
  • Production of look-a-like placebo dosage forms

solid drug machine

Once your product, appropriate comparator drugs, and/or placebos have been rendered identical in appearance, UIP can sort them by weight to ensure the weight of every dosage unit is within the confirmed weight range. UIP can package finished products into bottles or bulk containers and apply labeling. Patient kits can be assembled and supplies can be shipped straight to clinical sites.

To learn more about our ability to prepare comparator drugs for clinical trials, or our how we manufacture and package comparator drugs and other products, please Contact Us.