University of Iowa

Lyophilization Cycle Development Equipment in Place

UIP has completed installation of a Lyotherm 2 and Lyostat 2 from Biopharma Technology Limited. The Lyotherm 2 provides integrated differential thermal analyser (DTA) and electrical impedance (Zsinφ) capability in a single instrument. The Lyotherm 2 is designed to measure glass transition (Tg'), eutectic (Teu) and melting (Tm) temperatures relevant to freeze-drying formulations.  The Lyostat 2 is a fully integrated freeze-drying microscope that enables critical events such as collapse and melting to be observed in situ, as well as characteristics such as skin or crust formation to be observed and identified.  The coupled Lyostat 2 and Lyotherm 2 units provide valuable information for both formulation and cycle development processes. With UIP in-house expertise in lyophilization, the purchase of this system will allow quicker and more efficient development of lyophilization cycles. In fact, already during installation testing and training, UIPDC staff were able to discover a potential solution to a lyophilization challenge presented by a research project.