University of Iowa

Lyophilization Cycle Development Equipment Ordered

UIP issued a purchase order for a Lyotherm 2 and Lyostat 2 from Biopharma Technology Limited. The Lyotherm 2 provides integrated differential thermal analyzer (DTA) and electrical impedance (Zsinφ) capability in a single instrument. The Lyotherm 2 is designed to measure glass transition (Tg'), eutectic (Teu), and melting (Tm) temperatures relevant to freeze-drying formulations.  The Lyostat 2 is a fully integrated freeze-drying microscope that enables critical events such as collapse and melting to be observed in situ, as well as characteristics such as skin or crust formation to be observed and identified.  The coupled Lyostat 2 and Lyotherm 2 units provide valuable information for both formulation and cycle development processes. With UIP in-house expertise in lyophilization, the purchase of this system will allow quicker and more efficient development of lyophilization cycles.